Dose Weight Gain in Lean Patients with Polycystic Ovary Syndrome Improves Ovulation and Pregnancy Rates?

Objective: To evaluate the effect of weight gain in lean patients with polycystic ovary syndrome (PCOS) on ovulation and pregnancy rates.Material and methods: Lean patients with PCOS seeking fertility were invited to participate in the study. Weight gain was commenced by dietary modifications. Patients were classified later into respondent and non-respondent. All patients were stimulated with Letrozole ۲.۵ mg twice daily for five days for six cycles. Ovulation and pregnancy rates were assessed.  Results: From ۸۴ patients who were enrolled in our study, ۳۳ patients were allocated into non responder group and ۲۸ patients were allocated to the responder group, and it was found that despite there was statistical difference between both groups as regard weight gain, weight after six months and BMI after six months, there was no significant difference between both groups as regard the ovulation rate, pregnancy rate and complications to ovulation induction ovarian hyperstimulation syndrome (OHSS).Conclusion: weight gain in lean PCOS patients - although non-significant- but it may improve the reproductive outcomes (ovulation rate and pregnancy rate) and the need of further study with larger number and longer duration of follow up for confirmation of these results.

Keywords:

weight gain , Lean patients , PCOS , infertility , Ovulation , Pregnancy