Clinical, Laboratory and Imaging Characteristics of Women with Uterine Fibroid: A Cross-Sectional Study from Iran

Background and Objective: Uterine fibroids (UFs) the most common pelvic tumors among women at reproductive age affecting women’s quality of life even their confidence with its symptoms. We designed a study to investigate the clinical, laboratory, and imaging characteristics of Iranian women with UF.Methods: This cross-sectional study was performed April ۲۰۱۶- September ۲۰۲۲ at Imam Hossein hospital (Tehran, Iran). We included all women with UF referring to the Obstetrics and Gynecology Clinic of Imam Hossein Hospital. Based on a checklist a research team interviewed the patients to investigate clinical characteristics. Also we explored laboratory and transvaginal sonography (TVS) findings of all patients. Results: The mean age of ۴۳۹ studied patients was ۴۴.۴۷±۸.۸۰ years (range: ۲۳-۸۱). The most prevalent underlying disease was hypertension (۱۷.۱%), followed by thyroid diseases (۱۵.۷%) and diabetes mellitus (۱۳.۷%). The patients mainly complained of AUB (abnormal menstrual bleeding) (۶۰.۰%), abdominal pain (۲۳.۷%). The mean NLR (neutrophil to lymphocyte ratio) and the mean PLR (platelet to lymphocyte ratio) were significantly higher than the normal upper limit (P<۰.۰۰۱). Largest diameter of UF was ۴۹.۸۹±۴۷.۹۲ mm. Most fibroids were located anteriorly (۴۳.۱%). The multivariate linear regression model revealed that age (β=-۰.۹۳۱, ۹۵%CI= (-۱.۶۵۷, -۰.۲۰۴), P=۰.۰۱۲) and number of fibroid (β=۲۲.۴۱۸, ۹۵%CI= (۱۶.۳۶۰, ۲۸.۴۷۶), P<۰.۰۰۱) could predict the size of fibroid. Conclusion: Our results showed that NLR and PLR were increased in UF patients. It seems that patient’s age and number of fibroid may be the predict factors for UF's size. Keywords: Abnormal Uterine Bleeding, hypertension, Neutrophil, Leiomyoma, Lymphocyte, Ultrasonography.

Keywords:

Abnormal uterine bleeding , hypertension , NEUTROPHIL , Leiomyoma , Lymphocyte , Ultrasonography