Diagnosis of Latent Tuberculosis Infection: Promising Antigens

Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
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JR_IJMM-17-5_002

تاریخ نمایه سازی: 30 بهمن 1402

Abstract:

Latent tuberculosis infection (LTBI) prevalence varies dramatically by region, with one-fourth of the world's population infected. The number of people with LTBI progressing to active tuberculosis illness (aTB) should be decreased to meet the WHO End TB Strategy objective of decreasing worldwide tuberculosis incidence by ۲۰۳۰. Current tuberculosis (TB) diagnostic methods are based on detecting an immune response to mycobacterial antigens injected into the skin or in vitro simulations in interferon-gamma release assays. Both tests have low sensitivity, which cannot distinguish between LTBI and aTB. Therefore, various techniques, such as alternate cytokine detection and employing novel antigens, are being studied to increase the accuracy of these tests.  In addition, novel antigens can be used to monitor aTB progression and response to treatment. This review aims to assess current available diagnostic tools and evidence on novel Mycobacterium tuberculosis (Mtb) antigens for LTBI diagnosis and select the most promising antigens for future research.

Authors

Najmeh Jomehpour

Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Saman Soleimanpour

Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Mojtaba Sankian

Immunology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

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