Histidine rich protein ۲ performance in determining the prevalence of Malaria among patients presenting with clinical symptoms of Malaria

Chika Okangba; Charles J. Elikwu; Emmanuel O. Shobowale; Opeoluwa Shonekan; Victor Nwadike; Babatunde Tayo; Azubuike C. Omeonu; Bibitayo Faluyi; Chiamaka Meremikwu; Oyindamola Falade; Demilade Osoba; Tolulope Binuyo; Akinboboye Olutosin

Histidine rich protein 2 performance in determining the prevalence of Malaria among patients presenting with clinical symptoms of Malaria

Publish place: Scientific Journal of Pure and Applied Sciences، Vol: 5، Issue: 1

Publish Year: 1395

Type: Journal paper

Language: English

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https://civilica.com/doc/1920883

Document National Code:

JR_SJPAS-5-1_003

Index date: 22 February 2024

Histidine rich protein 2 performance in determining the prevalence of Malaria among patients presenting with clinical symptoms of Malaria abstract

Malaria rapid diagnostic test (RDT) is an antigen capture assay that enables rapid diagnosis of malaria without the need for electricity or highly skilled technicians. Though potentially useful, its adoption needs to be guided by local test sensitivity. This study evaluated the diagnostic performance of a commercially available RDT among 200 febrile patients (aged 2months to 72 years) in Ellison, Ogun State Nigeria. It was a prospective observational study conducted at the Babcock Teaching Hospital (BUTH) between February and June, 2015. Finger prick blood samples were collected from each of the patients (day 0) and immediately tested for P. falciparum malaria by both Giemsa microscopy and rapid diagnostic test (RDT). The prevalence of malaria among the study cohort was 15.0% by microscopy and 17.0% by RDT. The RDT had a sensitivity of 83.3% and specificity of 94.7%; with positive and negative predictive values of 73.5% and 96.9% respectively. The diagnostic performance of the RDT in this study was good. Hence, it is recommended as an alternative method for diagnosis of malaria, especially when microscopy is not feasible.Malaria rapid diagnostic test (RDT) is an antigen capture assay that enables rapid diagnosis of malaria without the need for electricity or highly skilled technicians. Though potentially useful, its adoption needs to be guided by local test sensitivity. This study evaluated the diagnostic performance of a commercially available RDT among 200 febrile patients (aged 2months to 72 years) in Ellison, Ogun State Nigeria. It was a prospective observational study conducted at the Babcock Teaching Hospital (BUTH) between February and June, 2015. Finger prick blood samples were collected from each of the patients (day 0) and immediately tested for P. falciparum malaria by both Giemsa microscopy and rapid diagnostic test (RDT). The prevalence of malaria among the study cohort was 15.0% by microscopy and 17.0% by RDT. The RDT had a sensitivity of 83.3% and specificity of 94.7%; with positive and negative predictive values of 73.5% and 96.9% respectively. The diagnostic performance of the RDT in this study was good. Hence, it is recommended as an alternative method for diagnosis of malaria, especially when microscopy is not feasible.

Histidine rich protein 2 performance in determining the prevalence of Malaria among patients presenting with clinical symptoms of Malaria Keywords:

Malaria , Rapid diagnostic test , Microscopy , Ilishan-Remo , Nigeria

Histidine rich protein 2 performance in determining the prevalence of Malaria among patients presenting with clinical symptoms of Malaria authors

Chika Okangba