Prevalence of Mycobacterium tuberculosis mutations associated with isoniazid and rifampicin resistance: A systematic review and meta-analysis
Publish place: 24th International Congress of Microbiology of Iran
Publish Year: 1402
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
MEDISM24_161
تاریخ نمایه سازی: 6 اسفند 1402
Abstract:
Tuberculosis (TB) is still one of the leading causes of worldwide death, especially following the emergence of strains resistant to isoniazid (INH) and rifampicin (RIF). This study aimed to systematically review published articles focusing on the prevalence of INH and/or RIF resistance-associated mutations of Mycobacterium tuberculosis isolates in recent years. Literature databases were searched using appropriate keywords. The data of the included studies were extracted and used for a random-effects model meta-analysis. Of the initial ۱۴۴۲ studies, ۲۹ were finally eligible to be included in the review.The overall resistance to INH and RIF was about ۱۷.۲% and ۷.۳%, respectively. There was no difference between the frequency of INH and RIF resistance using different phenotypic or genotypic methods. The INH and/or RIF resistance was higher in Asia. The S۳۱۵T mutation in KatG (۲۳.۷ %), C-۱۵T in InhA (۱۰.۷ %), and S۵۳۱L in RpoB (۱۳.۵ %) were the most prevalent mutations. Altogether, the results showed that due to S۵۳۱L in RpoB, S۳۱۵T in KatG, and C-۱۵T in InhA mutations INH- and RIF-resistant M. tuberculosis isolates were widely distributed. Thus, it would be diagnostically and epidemiologically beneficial to track these gene mutations among resistant isolates.
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Authors
Sara Kooti
Behbahan Faculty of Medical Sciences, Behbahan, Iran
Sepide Kadivarian
Department of Microbiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Mosayeb Rostamian
Infectious Diseases Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Ramin Abiri
Fertility and Infertility Research Center, Research Institute for Health Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Amirhooshang Alvandi
Medical Technology Research Center, Research Institute for Health Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.