Evaluation of Liver Enzymes, Hematologic and Coagulation Factors in Patients with Chronic Kidney Disease

Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
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JR_TUMS-5-4_004

تاریخ نمایه سازی: 8 اسفند 1402

Abstract:

Introduction: Chronic Kidney Disease (CKD) is a condition where the kidneys have abnormal structure or function that lasts for more than three months, can have negative health effects, and often does not show symptoms in the beginning. In that research, we tried to examine the diagnostic markers from the laboratory to find clues for a faster diagnosis of this disease.Methods: This paper is a cross-sectional analytical study on ۱۰۷ patients with CKD hospitalized in Abadan University of Medical Sciences educational hospitals from March ۲۱, ۲۰۱۷, to March ۱۹, ۲۰۲۰. Once the necessary permits were obtained, the laboratory information of patients was received from HIS. The data was analyzed by SPSS version ۱۶ software. Statistical significance is considered when P-value>۰.۰۵.Results: Out of ۱۰۷ patients with CKD in the study, ۵۵ (۵۱.۴%) were female and ۵۲ (۴۸.۶%) were male. The mean age of the group was ۵۷.۹±۱۷.۴۲ years. The means of renal diagnostic markers such as creatinine ۷.۴۲±۴.۵۵ and BUN ۵۶.۹۷±۳۶.۷۸ were higher than normal. Also, the mean coagulation markers, including PT (۱۵.۸۶±۹.۸۹), PTT (۴۷.۶۵±۲۹.۱۱), and INR (۱.۵۴±۱.۰۷), were higher than normal. The mean of hematological diagnostic markers, including hemoglobin and hematocrit, was lower than normal. The mean RDW-CV (۱۶.۹۷±۴.۱۹) and white blood cells (۱۱.۱۹±۹.۰۱) were higher than normal.Conclusions: This study showed that renal markers (creatinine and BUN) and coagulation factors (PT, PTT, and INR) were higher than normal. In this study, it was observed that people with CKD are prone to anemia because a decrease in the mean hemoglobin and hematocrit and an increase in RDW-CV were observed.

Authors

Alireza Balizadeh Karami

Student Research Committee, Abadan University of Medical Sciences, Abadan, Iran

Atefeh Zahedi

Department of Public Health, Asadabad School of Medical Sciences, Asadabad, Iran

Naser Kamyari

Department of Public Health, School of Health, Abadan University of Medical Sciences, Abadan, Iran

Hoda Mojiri-Forushani

Department of Pharmacology, School of Medicine, Abadan University of Medical Sciences, Abadan, Iran

Tina Eghdampanah Foumani

Student Research Committee, Abadan University of Medical Sciences, Abadan, Iran

Mohammad Mehdi Shadravan

Student Research Committee, Abadan University of Medical Sciences, Abadan, Iran

Khadijeh Kanani

Clinical Research Development Unit, Taleghani Educational Hospital, Abadan University of Medical Sciences, Abadan, Iran

Esmat Radmanesh

Department of Physiology, School of Medicine, Abadan University of Medical Sciences, Abadan, Iran

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