The role of neurotransmitters (serotonin and dopamine) in central nervous system fatigue during prolonged exercise

The phenomena of fatigue of voluntary muscular effort is intricate and multidimensional in the field of sports sciences. The causes and effects of exercise-induced fatigue have been extensively studied, but the central nervous system's (CNS) involvement in this process is still unclear. In order to understand CNS fatigue after physical activity, the current review will examine changes in neurotransmitter function during exercise. Using primary sources such scientific journals and websites, a consensus and critical evaluation were carried out in order to accomplish this goal. For a number of neurotransmitters, including dopamine and serotonin (5-HT; 5-hydroxytryptamine), hypotheses have been established. The most well-known one is a rise in serotonin levels throughout the brain. Nutritional interventions intended to reduce brain serotonin synthesis during extended exercise enhance endurance performance, and there is strong evidence that increases and decreases in brain serotonin activity during prolonged exercise, respectively, accelerate and delay fatigue. There are several physiologically connected causes of fatigue. It is important to better understand how CNS effects affect fatigue in order to achieve maximum muscle performance in both daily life and athletics.

The role of neurotransmitters (serotonin and dopamine) in central nervous system fatigue during prolonged exercise Keywords:

Central Nervous , Fatigue , Physical Exercise , Serotonin , dopamine