Comparison of Lipids and Lipoprotein Levels of Cord Blood in Neonates in Ahwaz City with the Same Parameters in Nelson Textbook of Pediatrics

Adult cardiovascular disease has its roots in childhood, Various surveys have shown a significant correlation between early atherosclerotic changes indentified at autopsy of children and young adults, and both total cholesterol (TC) and low-density lipoprotein (LDL cholesterol) levels. The hypercholesterolemic neonates time for diagnosis of high risk neonate infants. The aim of this study is to compare the lipids and lipoproteins levels of cord blood with the same parameters in Nelson textbook of pediatrics. This is a cross sectional study on umbilical cord blood of ۲۴۳ full term newborn infants (۱۱۴ females and ۱۲۹ males) who were born at the Razi Hospital of Ahwas University from March to September of ۲۰۰۲. For the collection of data we used the nonprobabilitic sampling. Complicated and abnormal cases were eliminated. The mean of TC, LDL-C, HDL-C and TG were: ۸۱.۰۲±۱۹.۷۵mg/dl, ۴۸.۹۲±۱۶.۳۹ mg/dl, ۲۵.۰۹±۷.۳۴ mg/dl and ۴۲±۲۹.۱۰ mg/dl. The result showed that the mean of T.C., LDL C and TG. was significantly more than that of Nelson textbook (P=۰.۰۰۰۱). The mean of HDL C. was significantly less than that of Nelson textbook (P=۰.۰۰۰۱). Also the prevalence of hypercholesterolemia in neonatal infants is significantly more than that of Nelson textbook. In this study, the mean of lipids and lipoproteins was compared between males and females. The mean of TC and LDL C. in females is significantly more than male neonates (P=۰.۰۱۶ and P۰.۰۰۷). Therefore, this community is at high risk. Because the neonates with hypercholesterolemia will be more liable to face this problem in adulthood, measuring of cord blood lipids and lipoproteins is a priority in this community. Lipids profiles of parents and other ۱st –degree relatives are also necessary to establish whether there is a dominantly inherited defect responsible for the hypercholoesterolemia.

Keywords:

Lipid , Lipoprotein , Hypercholestrolemia , Cord blood , neonate , Gender