In Vitro Evaluation of the Effects of Pelargonium quercetorum Agnew Extracts on Trichomonas vaginalis

Background: Trichomonas infection is a common sexually transmitted infection, and concerns about drug resistance to this infection are increasing. The aim of this study was to evaluate the in vitro activity of Pelargonium quercetorum extracts on Trichomonas protozoans. Methods: One isolate of Trichomonas vaginalis was subjected to susceptibility testing against ethyl acetate, n-hexane, and aqueous extracts of P. quercetorum using the microtiter plate method. The minimum lethal concentration (MLC) of the extracts was measured in comparison with metronidazole under aerobic conditions. Results: All extracts had antiprotozoal activities against Trichomonas. After ۴۸-hour exposure, the most antitrichomonal activity of the extracts belonged to the ethyl acetate, with an MLC of ۲۵۰ µg/mL, followed by the n-hexane (۵۰۰ µg/mL) and aqueous (۲۵ mg/mL) extracts in comparison with metronidazole, with an MLC of ۳.۱ µg/mL. Conclusion: The results of this study indicated that P. quercetorum has potential properties against Trichomonas protozoans, although further studies are needed to evaluate the antiprotozoal activity of its components.