Comparison of plasma fibrinogen level in opium addict men with non-addict men

fibrinogen is one of the plasma proteins synthetzed by the liver.elevated plasma fibrinogen is an independent coronary artery disease(CAD) risk factor and increases the risk of thrombus formation.this study was performed to compare the plasma fibrinogen level in opium addict men with non opium users.each group consisted of ۶۰ males,who didnot smoke cigarettes and were not suffered from diabetes mellitus,hyperlipidemia and hypertension.mean age was ۴۶.۶+_۳ and ۴۵.۷+_۳.۶ years in opium addict and control group rerespectively.the mean level of plasma fibrinogen for the opium addict group was significantly higher than that of control group(۳۱۹.۱+_۵۸.۳ mg/dl vs ۲۹۵.۷+_۴۸.۳ mg/dl, p=۰.۰۱۸).there was ni significant difference between two groups regarding other parameters (CBC,Hb,Hct,TC,TG,Cr), but plasma urea in control group was significantly higher than addict group (p=۰.۰۰۸). our study revealed that plasma fibrinogen level in opium addicted men was significantly higher than non-opium users.

Keywords:

fibrinogen , Opium , Addiction , Atherosclerosis , cononary artery disease