Evaluation of propylthiouracil effect on rat,s ovarian activity

this study  Evaluation the physiological activity effects of thyroid glands on the process of development and growth of ovaries and reproductive organs in rats.the study also investigates the adverse effects of antithyroid compounds adminidtered to mothers during lactation period on the developmental process of the newborn rat,s reproductive organs and the level of sexual hormones.the early and reversible hypothyroidism were induced in newborn rat,s viaPTU(propylthiouracil) solved in mothers, drinking water in order to study the development of reproductive organs.the results indicated a significant decrease(p<۰.۰۰۰۱) in the weight of PTU (propylthiouracil) treated animals when compared to the controls.the level of protein synthesis on ۴۵,۵۵ and ۶۵ days of age showed a significant derease (p<۰.۰۰۱,p<۰.۰۱ and p<۰.۰۰۱ respectively) in comparison to the controls.however no effect on non-endocrine organs,such as kidneys and spleen were observed.the determination of FSH and LH serum level and the comparison of results in the treated animals and controls revealed that LH levels were not significant when the animals were ۳۵ days old,but from the age of ۴۵-۵۵ and ۶۰-۷۰ days.the values were significant(P>۰.۰۱ and p<۰.۰۰۱ respectively),when compared to the control groups.the FSH serum density showed a decline up to the ۳۵ days of life (p<۰.۰۱) and since then showed an upwared increase up to the ۵۶ days of age(p<۰.۰۱).however the onset of puberty in treated animals was delayed.this may happen due to up-regulation phenomena.

Keywords:

propylthiouracil , gonadotropine , Rat