Analgesic effect of hydroalcoholic extract of Zingiber and piper nigrum in mice by tail-flick test

in traditional medicine,some plants have been used as analysics.the aim of this investigation was to evaluate the analgesic effect of two plants,piper nigrum and Zingiber officinale that are used  traditionally to relieve headache,rheumatic arthritis,and toothache.for this purpose the methanolic extract of zingiber and piper nigrum,in different doses,were injected intraperitonealy to mice and the analgesic effect was determined by tail-flick apparatus.the results show that the suxhleted extract of piper nigrum with dose of ۵۰ and ۷۵ mg/kg of body weight did not induce significant analgesia in comparison to the control group but of ۱۰۰mg/kg induced significant analgesia.this analgesia effect was maximum at ۹۰ min after injection of the extract (p<۰.۰۱).the analgesia response fron this dose was also significant at ۱۵ (p<۰.۰۵) ۳۰,۴۵ and ۶۰ min after the injection (p<۰.۰۱) compared to the control group.injection of the perulated extract and this difference to analgesia effect between the two extracts was maximum at ۹۰min post-injection(p<۰.۰۱).the difference to analgesia effect was also significant at ۳۰ min.(p<۰.۰۱) and ۶۰min after injection (p<۰.۰۵).the results from the experiment of zingiber showed that the injection of perculated extract of zingiber to mice with doses of ۵۰,۷۵ and ۱۰۰ mg/kg induced significant analgesia at ۳۰,۴۵,۶۰ min(p<۰.۰۱) and ۹۰min (p<۰.۰۵) post-injection in comparison with the control group.this response reached maximum at ۴۵ min post-injection and reduced there after.injection of suxhleted extract with doses of ۱۰۰mg/kg induced lower analgesic effect than the same dose of perculated extract at ۴۵ min after the injection(p<۰.۰۱).at the other times,analgesic responses between the extracts were not significantly different.

Keywords:

Zingiber , piper nigrum , analgesia , pain measurnet , Tail-flick