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Novel drugs affecting diabetic peripheral neuropathy

Publish Year: 1403
Type: Journal paper
Language: English
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JR_IJBMS-27-6_001

Index date: 18 March 2024

Novel drugs affecting diabetic peripheral neuropathy abstract

Diabetic peripheral neuropathy (DPN) poses a significant threat, affecting half of the global diabetic population and leading to severe complications, including pain, impaired mobility, and potential amputation. The delayed manifestation of diabetic neuropathy (DN) makes early diagnosis challenging, contributing to its debilitating impact on individuals with diabetes mellitus (DM). This review examines the multifaceted nature of DPN, focusing on the intricate interplay between oxidative stress, metabolic pathways, and the resulting neuronal damage. It delves into the challenges of diagnosing DN, emphasizing the critical role played by hyperglycemia in triggering these cascading effects. Furthermore, the study explores the limitations of current neuropathic pain drugs, prompting an investigation into a myriad of pharmaceutical agents tested in both human and animal trials over the past decade. The methodology scrutinizes these agents for their potential to provide symptomatic relief for DPN. The investigation reveals promising results from various pharmaceutical agents tested for DPN relief, showcasing their efficacy in ameliorating symptoms. However, a notable gap persists in addressing the underlying problem of DPN. The results underscore the complexity of DPN and the challenges in developing therapies that go beyond symptomatic relief. Despite advancements in treating DPN symptoms, there remains a scarcity of options addressing the underlying problem. This review consolidates the state-of-the-art drugs designed to combat DPN, highlighting their efficacy in alleviating symptoms. Additionally, it emphasizes the need for a deeper understanding of the diverse processes and pathways involved in DPN pathogenesis.

Novel drugs affecting diabetic peripheral neuropathy authors

Dalia O. Saleh

Pharmacology Department, Medical Research and Clinical Studies Institute, National Research Centre, ۱۲۶۲۲, Egypt

Ahmed Sedik

Pharmacology Department, Medical Research and Clinical Studies Institute, National Research Centre, ۱۲۶۲۲, Egypt

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Juster-Switlyk K, Smith AG. Updates in diabetic peripheral neuropathy. F۱۰۰۰Res ...
Yoo M, Sharma N, Pasnoor M, Kluding PM. Painful diabetic ...
Oliver TI, Mutluoglu M. Diabetic Foot Ulcer. StatPearls. Treasure Island ...
Abdissa D. Prevalence and associated factors of painful diabetic peripheral ...
A Sedik A. Modulation activity of vildagliptin on hepatic complications ...
Dobretsov M, Romanovsky D, Stimers JR. Early diabetic neuropathy: Triggers ...
Feldman EL, Callaghan BC, Pop-Busui R, Zochodne DW, Wright DE, ...
Stino AM, Smith AG. Peripheral neuropathy in prediabetes and the ...
Anandhanarayanan A, Teh K, Goonoo M, Tesfaye S, Selvarajah D. ...
Tesfaye S, Boulton AJ, Dickenson AH. Mechanisms and management of ...
Yu Y. Gold Standard for Diagnosis of DPN. Front Endocrinol ...
Cohen K, Shinkazh N, Frank J, Israel I, Fellner C. ...
Sadosky A, Schaefer C, Mann R, Bergstrom F, Baik R, ...
Tesfaye S, Selvarajah D. Advances in the epidemiology, pathogenesis and ...
Shillo P, Sloan G, Greig M, Hunt L, Selvarajah D, ...
Sifuentes-Franco S, Pacheco-Moisés FP. The role of oxidative stress, mitochondrial ...
Yagihashi S, Mizukami H, Sugimoto K. Mechanism of diabetic neuropathy: ...
Qureshi Z, Ali MN. An insight into potential pharmacotherapeutic agents ...
Yang H, Sloan G, Ye Y, Wang S, Duan B, ...
Finnerup NB, Attal N, Haroutounian S, McNicol E, Baron R, ...
Javed S, Petropoulos IN, Alam U, Malik RA. Treatment of ...
Luo X, Wu J, Jing S, Yan L-J. Hyperglycemic stress ...
Chowdhury SKR, Smith DR, Fernyhough P. The role of aberrant ...
Arora K, Tomar PC, Mohan V. Diabetic neuropathy: An insight ...
Goto Y, Hotta N, Shigeta Y, Sakamoto N, Kikkawa R. ...
Chalk C, Benstead TJ, Moore F. Aldose reductase inhibitors for ...
Coppey LJ, Gellett JS, Davidson EP, Dunlap JA, Yorek MA. ...
Matsumoto T, Ono Y, Kurono M, Kuromiya A, Nakamura K, ...
Singh Grewal A, Bhardwaj S, Pandita D, Lather V, Singh ...
Oyenihi AB, Ayeleso AO, Mukwevho E, Masola B. Antioxidant strategies ...
Schleicher ED, Weigert C. Role of the hexosamine biosynthetic pathway ...
Stracke H, Gaus W, Achenbach U, Federlin K, Bretzel R. ...
Bönhof GJ, Sipola G, Strom A, Herder C, Strassburger K, ...
Popa AR, Bungau S, Vesa CM, Bondar AC, Pantis C, ...
Mousa SA, Shaqura M, Winkler J, Khalefa BI, Al-Madol MA, ...
Wang S, Joseph J, Ro JY, Chung M-K. Modality-specific mechanisms ...
Zan Y, Kuai C-X, Qiu Z-X, Huang F. Berberine ameliorates ...
Bansal D, Badhan Y, Gudala K, Schifano F. Ruboxistaurin for ...
Galvez MI. Protein kinase C inhibitors in the treatment of ...
Pacher P, Szabó C. Role of poly (ADP-ribose) polymerase-۱ activation ...
Dewanjee S, Das S, Das AK, Bhattacharjee N, Dihingia A, ...
Ilnytska O, Lyzogubov VV, Stevens MJ, Drel VR, Mashtalir N, ...
Obrosova IG, Xu W, Lyzogubov VV, Ilnytska O, Mashtalir N, ...
Xu S, Li J, Zhai M, Yao X, Liu H, ...
Rhee SY, Kim YS. The role of advanced glycation end ...
Xu S, Bao W, Men X, Liu Y, Sun J, ...
Zhang X, Xu L, Chen W, Yu X, Shen L, ...
Hosseini A, Abdollahi M. Diabetic neuropathy and oxidative stress: therapeutic ...
Basit A, Basit KA, Fawwad A, Shaheen F, Fatima N, ...
Sedik AA, Hassan A, Saleh DO. Neuromodulatory role of L-arginine: ...
Sedik AA, Hassan SA, Shafey HI, Khalil WK, Mowaad NA. ...
Sedik AA, Amer AA. Modulatory effects of cilostazol; An Nrf۲/HO-۱ ...
Yerra VG, Negi G, Sharma SS, Kumar A. Potential therapeutic ...
Mijnhout G, Alkhalaf A, Kleefstra N, Bilo H. Alpha lipoic ...
Reljanovic M, Reichel G, Rett K, Lobisch M, Schuette K, ...
Di Stefano G, Di Lionardo A, Galosi E, Truini A, ...
Kuhad A, Chopra K. Tocotrienol attenuates oxidative-nitrosative stress and inflammatory ...
Dong J, Zuo Z, Yan W, Liu W, Zheng Q, ...
Ranjithkumar R, Prathab Balaji S, Balaji B, Ramesh R, Ramanathan ...
Sandireddy R, Yerra VG, Komirishetti P, Areti A, Kumar A. ...
Rasoulian B, Hajializadeh Z, Esmaeili-Mahani S, Rashidipour M, Fatemi I, ...
Kishore L, Kaur N, Singh R. Effect of Kaempferol isolated ...
Chen Y-W, Hsieh P-L, Chen Y-C, Hung C-H, Cheng J-T. ...
Purwata TE. High TNF-alpha plasma levels and macrophages iNOS and ...
Khalifa M, Fayed R, Sedik AA, Khalil HM. Dose-dependent toxic ...
Jin HY, Park TS. Role of inflammatory biomarkers in diabetic ...
Zychowska M, Rojewska E, Kreiner G, Nalepa I, Przewlocka B, ...
Syngle A, Verma I, Krishan P, Garg N, Syngle V. ...
Daugherty DJ, Marquez A, Calcutt NA, Schubert D. A novel ...
Kandimalla R, Dash S, Kalita S, Choudhury B, Malampati S, ...
Zhang BY, Zhang YL, Sun Q, Zhang PA, Wang XX, ...
Sandireddy R, Yerra VG, Komirishetti P, Areti A, Kumar A. ...
Cosentino F, Eto M, De Paolis P, van der Loo ...
Suarez-Mendez S, Tovilla-Zarate CA, Ortega-Varela LF, Bermudez-Ocana DY, Ble-Castillo JL, ...
Kimura S, Kontani H. Demonstration of antiallodynic effects of the ...
Matsunaga A, Kawamoto M, Shiraishi S, Yasuda T, Kajiyama S, ...
Price S, Agthong S, Middlemas A, Tomlinson D. Mitogen-activated protein ...
Zheng X, Chen L, Du X, Cai J, Yu S, ...
Zhou J, Du X, Long M, Zhang Z, Zhou S, ...
Zhang S, Hulver MW, McMillan RP, Cline MA, Gilbert ER. ...
Rahman MH, Jha MK, Kim J-H, Nam Y, Lee MG, ...
Katayama Y, Kawata Y, Moritoh Y, Watanabe M. Dichloroacetate, a ...
Liu S, Zou L, Xie J, Xie W, Wen S, ...
Ren X, Yang R, Li L, Xu X, Liang S. ...
Liu XS, Fan B, Szalad A, Jia L, Wang L, ...
Fan B, Li C, Szalad A, Wang L, Pan W, ...
Waterman RS, Morgenweck J, Nossaman BD, Scandurro AE, Scandurro SA, ...
Rosenberger DC, Blechschmidt V, Timmerman H, Wolff A, Treede R-D. ...
Schreiber AK, Nones CF, Reis RC, Chichorro JG, Cunha JM. ...
Pop-Busui R, Boulton AJ, Feldman EL, Bril V, Freeman R, ...
Dworkin RH, O’Connor AB, Audette J, Baron R, Gourlay GK, ...
Sultan A, Gaskell H, Derry S, Moore RA. Duloxetine for ...
Lindsay TJ, Rodgers BC, Savath V, Hettinger KD. Treating diabetic ...
Saarto T, Wiffen PJ. Antidepressants for neuropathic pain. Cochrane Database ...
Boulton AJ. Management of diabetic peripheral neuropathy. Clin Diabetes ۲۰۰۵; ...
Sansone RA, Sansone LA. Serotonin norepinephrine reuptake inhibitors: a pharmacological ...
Food U, Administration D. drugs@ FDA. http://www accessdata fda gov/scripts/cder/drugsatfda/ ...
Max MB, Kishore-Kumar R, Schafer SC, Meister B, Gracely RH, ...
Quilici S, Chancellor J, Löthgren M, Simon D, Said G, ...
Kaur H, Hota D, Bhansali A, Dutta P, Bansal D, ...
Zhang T-T, Xue R, Fan S-Y, Fan Q-Y, An L, ...
Allen R, Sharma U, Barlas S. Clinical experience with desvenlafaxine ...
Li N, Li C, Han R, Wang Y, Yang M, ...
Ulugol A, Karadag HC, Tamer M, Firat Z, Aslantas A, ...
Max MB, Lynch SA, Muir J, Shoaf SE, Smoller B, ...
Morello CM, Leckband SG, Stoner CP, Moorhouse DF, Sahagian GA. ...
Joss JD. Tricyclic antidepressant use in diabetic neuropathy. Ann Pharmacother ...
Goodman LS. Goodman and Gilman’s the pharmacological basis of therapeutics: ...
Price R, Smith D, Franklin G, Gronseth G, Pignone M, ...
Mihic SJ, Harris RA. GABA and the GABAA receptor. Alcohol ...
Taylor CP, Angelotti T, Fauman E. Pharmacology and mechanism of ...
Azmi S, ElHadd KT, Nelson A, Chapman A, Bowling FL, ...
Cai K, Nanga RP, Lamprou L, Schinstine C, Elliott M, ...
Wiffen PJ, Derry S, Bell RF, Rice AS, Tölle TR, ...
Chincholkar M. Gabapentinoids: Pharmacokinetics, pharmacodynamics and considerations for clinical practice. ...
Cui J-G, Linderoth B, Meyerson BA. Effects of spinal cord ...
Backonja M, Beydoun A, Edwards KR, Schwartz SL, Fonseca V, ...
Moore RA, Wiffen PJ, Derry S, Rice AS. Gabapentin for ...
Asrar MM, Kumari S, Sekhar BC, Bhansali A, Bansal D. ...
Rastogi A, Jude E. Novel treatment modalities for painful diabetic ...
Simmons Z, Feldman EL. The pharmacological treatment of painful diabetic ...
Chang G, Chen L, Mao J. Opioid tolerance and hyperalgesia. ...
Chou R, Fanciullo GJ, Fine PG, Adler JA, Ballantyne JC, ...
Pathan H, Williams J. Basic opioid pharmacology: An update. Br ...
Gimbel JS, Richards P, Portenoy RK. Controlled-release oxycodone for pain ...
Kahan M, Mailis-Gagnon A, Wilson L, Srivastava A. Canadian guideline ...
Machelska H, Celik MÖ. Advances in achieving opioid analgesia without ...
Gilron I, Bailey JM, Tu D, Holden RR, Weaver DF, ...
Yadlapalli JSK, Dogra N, Walbaum AW, Prather PL, Crooks PA, ...
Hoy SM. Tapentadol Extended Release. Drugs ۲۰۱۲; ۷۲:۳۷۵-۳۹۳ ...
Vadivelu N, Kai A, Maslin B, Kodumudi G, Legler A, ...
Harati Y, Gooch C, Swenson M, Edelman S, Greene D, ...
Freeman R, Raskin P, Hewitt DJ, Vorsanger GJ, Jordan DM, ...
Anwar M. Dextromethorphan. ۲۰۱۰. p. ۳۲۱-۳۲۴ ...
Weinbroum AA, Rudick V, Paret G, Ben-Abraham R. The role ...
Ware MA, Fitzcharles MA, Joseph L, Shir Y. The effects ...
Schifilliti C, Cucinotta L, Fedele V, Ingegnosi C, Luca S, ...
Nirogi R, Jabaris SL, Jayarajan P, Abraham R, Shanmuganathan D, ...
Westlake S, Jones M, Sharma KD, Xie JY. Letters to ...
Bernier LP, Ase AR, Séguéla P. P۲X receptor channels in ...
Ursu D, Ebert P, Langron E, Ruble C, Munsie L, ...
Jarvis MF, Burgard EC, McGaraughty S, Honore P, Lynch K, ...
Krajewski JL. P۲X۳-containing receptors as targets for the treatment of ...
Rao S, Liu S, Zou L, Jia T, Zhao S, ...
Jiang W, Fan W, Gao T. Analgesic mechanism of sinomenine ...
Balogh M, Aguilar C, Nguyen NT, Shepherd AJ. Angiotensin receptors ...
Keppel Hesselink JM, Schatman ME. EMA۴۰۱: An old antagonist of ...
Rice A, Dworkin R, McCarthy T, Anand P, Bountra C, ...
Rice ASC, Dworkin RH, Finnerup NB, Attal N, Anand P, ...
Emery EC, Luiz AP, Wood JN. Nav۱.۷ and other voltage-gated ...
McDonnell A, Collins S, Ali Z, Iavarone L, Surujbally R, ...
Bianchi R, Cervellini I, Porretta-Serapiglia C, Oggioni N, Burkey B, ...
Jayaraj ND, Bhattacharyya BJ, Belmadani AA, Ren D, Rathwell CA, ...
Nair AS. Tanezumab: Finally a monoclonal antibody for pain relief. ...
Bramson C, Herrmann DN, Carey W, Keller D, Brown MT, ...
Zha K, Yang Y, Tian G, Sun Z, Yang Z. ...
Apfel SC. Nerve growth factor for the treatment of diabetic ...
Barker PA, Mantyh P, Arendt-Nielsen L, Viktrup L. Nerve Growth ...
Kessler JA, Smith AG, Cha BS, Choi SH, Wymer J, ...
Alam U, Sloan G, Tesfaye S. Treating pain in diabetic ...
Buksnys T, Armstrong N, Worthy G, Sabatschus I, Boesl I, ...
Derry S, Rice AS, Cole P, Tan T, Moore RA. ...
Rayman G, Baker NR, Krishnan ST. Glyceryl trinitrate patches as ...
Intiso D, Basciani M, Santamato A, Intiso M, Di Rienzo ...
Gardner-Nix JS. Oral methadone for managing chronic nonmalignant pain. J ...
De Conno F, Groff L, Brunelli C, Zecca E, Ventafridda ...
de Vos CC, Meier K, Zaalberg PB, Nijhuis HJ, Duyvendak ...
van Beek M, Geurts JW, Slangen R, Schaper NC, Faber ...
Basson A, Olivier B, Ellis R, Coppieters M, Stewart A, ...
Zhu G-C, Tsai K-L, Chen Y-W, Hung C-H. Neural mobilization ...
Ishibashi F, Tavakoli M. Impact of normoglycemia in reducing microvascular ...
Casadei G, Filippini M, Brognara L. Glycated hemoglobin (HbA۱c) as ...
Albers JW, Herman WH, Pop-Busui R, Feldman EL, Martin CL, ...
Ismail-Beigi F, Craven T, Banerji MA, Basile J, Calles J, ...
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