Effect of Oral Curcumin on Rheumatoid Arthritis Patients: A Double-Blind Randomized Clinical Trial

Background and Objective: Incomprehensive studies have examined the therapeutic and side effects of curcumin on the treatment of debilitating diseases, such as Rheumatoid Arthritis (RA). This study aimed to explore the anti-inflammatory effects of curcumin on RA. Materials and Methods: This double-blind clinical trial was carried out on ۶۴ RA patients with an erythrocyte sedimentation rate (ESR)-Disease Activity Score (DAS)-۲۸>۲.۶. The patients were then randomly divided into two groups of intervention and control. In addition to the routine treatment, the intervention group was treated with ۸۰-mg/day capsules of curcumin (nano-micelles). Further, the patients were followed up for three months, and clinical-laboratory examinations were recorded in this study. Results: There was no significant difference between the intervention and control groups regarding the trends of the disease activity indicators, including DAS-۲۸, disability index, physician assessment, and the number of tender joints (P>۰.۰۵). Further, a significant difference was found between the two groups in terms of pain score changes and the number of swollen joints. Additionally, the curcumin-treated subjects obtained lower mean pain and fewer swollen joints, compared to those in the control group (P<۰.۰۵). Conclusion: The present study revealed that curcumin had no significant therapeutic effects on reducing the activity of RA; however, no significant side effects were observed on the patients, and it also showed its analgesic effect well.

Keywords:

Curcumin , Disability , ESR-DAS-۲۸ , Rheumatoid Arthritis , Clinical Trial , Anti-Inflammatory Effects