Investigating the Role of ACE۲ Receptors in the Rate of COVID-۱۹ Infectivity in Smokers and Opioid Abusers: A Review
Publish place: Jorjani Biomedicine Journal، Vol: 11، Issue: 3
Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_JOBJ-11-3_005
تاریخ نمایه سازی: 18 اردیبهشت 1403
Abstract:
It seems necessary to understand the association of severe acute respiratory syndrome coronavirus ۲ (SARS-CoV-۲), which causes coronavirus disease ۲۰۱۹ (COVID-۱۹), with its entering bronchoalveolar and brain cells, which have a high concentration of angiotensin-converting enzyme ۲ (ACE۲). Although the virus infects healthy people, the rate of infection and mortality is higher and significant in vulnerable people, such as drug users and addicts who have acute and chronic respiratory disease. It also places a heavy economic burden on families and societies around the world. Thus, researchers are aiming to provide prevention and treatment strategies to people at risk. The purpose of the present study was to collect studies on the rate of infection with coronavirus in people who abuse drugs. Besides, the role of the ACE۲ receptor as a key factor in coronavirus infectivity in these people was investigated. Our narrative review on the relationship between COVID-۱۹ and opioid abuse and smoking, with consideration of ACE۲'s role, contains original and human studies. According to the results of the current study, those who smoke or are dependent on opioids are much more likely to experience COVID-۱۹-related respiratory side effects or even pass away.
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Authors
narges Marefati
Department of Physiology and Medical Physics, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
Hassan Ghoshooni
Department of Medical Microbiology, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
mostafa mahabadi
Department of Medical Microbiology, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
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