Value of Platelet to Lymphocyte Ratio in Nasopharyngeal Carcinoma Various Stages

Introduction: Nasopharyngeal Carcinoma (NPC) is among the most common head and neck cancer, significantly affecting the growth of human tumors. Therefore, this study aimed to investigate platelet-to-lymphocyte ratio (PLR) as a measure of inflammation in patients with various stages of NPC.Materials and Methods: This retrospective case-control study was conducted on patients diagnosed with NPC between ۲۰۱۶ and ۲۰۲۰ in Dr. Hasan Sadikin Bandung Hospital, Indonesia. Based on NPC classification criteria, patients were classified into early and advanced groups. Subsequently, the PLR ratio was calculated as the number of platelet divided by the absolute number of lymphocytes in the two groups, and the results were statistically analyzed using Unpaired T-test, Pearson, and Chi-square test.Results: A total of ۱۰۲ patients with an age range of ۴۰ to ۴۹ years were included in this study. A slight correlation of ۰.۲۷۲ (P<۰.۰۰۱) was observed between PLR and clinical stage, while NPC patients with PLR value > ۱۸۸ had a ۲.۷ times higher risk of advanced stage (RR=۲.۷۰۲).Conclusion: The PLR was significantly related to the clinical stage of NPC cancer.

Keywords:

Lymphocytes , Nasopharyngeal carcinoma , Platelet count , Plaletets-to-Lymphocyte Ratio , Prognosis