Effect of diabetes mellitus on the spectrum of uropathogens and the antimicrobial resistance in patients with urinary tract infection

Background: Patients with diabetes mellitus (DM) frequently experience urinary tract infections. Many studies indicated that diabetes patients experience higher treatment costs, morbidity, and death due to UTI as a result of the spread of resistant bacterial strains in hospitals. In the current study, we looked at how glycemic control affects diabetic patients'''' rates of UTI, the pathogens that cause them, the presence of multi-drug-resistant (MDR) and extensively drug-resistant (XDR) organisms, and the infections'''' relation to diabetes.Methods: Diabetes patients'''' midstream urine (MSU) samples were taken in a sterile, spotless, and dry wide-mouthed bottle. After following the standard methodology to collect and identify the organisms, disc diffusion antibiotic sensitivity tests were conducted. HbA۱c measured for all patients. Using the SPSS ۱۶.۰ version, the data were examined.Results: In the current study, ۵۰۰ diabetic patients provided urine samples, after analyzing of urines it was revealed that۱۸۹ (۳۷.۲%) of those individuals had UTI. Compared to ۵۹ patients with managed glycemia, ۱۳۰ individuals in the uncontrolled glycemic group experienced the most UTI cases. In both diabetic groups, females had a significantly higher prevalence of UTI than males (۸۸.۴% and ۱۱.۶%, respectively, 𝑃 < ۰.۰۰۴). ۵۲.۳% of women over ۴۶ with uncontrolled glycemia experienced UTIs. The most common bacterial isolate, E. coli, displayed ۵۸.۴% MDR. Conclusion: These findings demonstrate that, regardless of age or gender, glycemic control in diabetes patients is essential for decreasing UTI rates. It should be noted that, the best empirical treatment for diabetic patients with UTI should involve regular monitoring of the uropathogenic susceptibility patterns.

Keywords:

Uti , Diabetes mellitus , Antibacterial resistance , glycemia