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Therapeutic activities of the main bioactive compounds via modulating sirtuins: A review

Publish Year: 1403
Type: Journal paper
Language: English
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JR_MNBA-3-1_001

Index date: 18 May 2024

Therapeutic activities of the main bioactive compounds via modulating sirtuins: A review abstract

Multiple cellular processes such as inflammation and apoptosis have been regulated by sirtuin (SIRT) proteins as highly conserved signaling proteins in eukaryotes, prokaryotes, and archaea. These proteins can be regulated under the effects of bioactive compounds, specifically ones isolated or derived from medical plant species. SIRT proteins can be targeted by various compounds such as apigenin, luteolin, fisetin, myricetin, ferulic acid, berberine, butein, malvidin, catechin, curcuminoids, and quercetin. The anti-inflammatory effect of these metabolites has been found to up-regulation of sirtuin expression. It should be noted that activation and inhibition of SIRT proteins have different therapeutic results. For example, activation of SIRT1 hinders oxidative stress, inflammation, and apoptosis in cells. In this review, we will discuss the therapeutic effects of these metabolites on cardioprotective, obesity, osteoarthritis, neurodegenerative, and other inflammatory and metabolic diseases by modulating sirtuins.

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Therapeutic activities of the main bioactive compounds via modulating sirtuins: A review authors

Helen Poormazaheri

Department of Biology, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran

Nasim Zaman Samghabadi

Department of Infectious Diseases, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Razieh Bagheri Shahzadeh Aliakbari

College of Applied and Natural Sciences, Louisiana Tech University, Ruston, Louisiana, ۷۱۲۷۲, USA