Higher score of Patient-Generated Subjective Global Assessment is a risk factor for Upper Gastrointestinal Cancers in Newly Diagnosed Patients

Background: Malnutrition or risks of malnutrition can be detected with the Patient-Generated Subjective Global Assessment (PG-SGA), a tool widely used to detect malnutrition. Debilitating diseases such as cancer cause serious physical, mental, and social harm. This study aimed to determine the relationship between malnutrition or risks of malnutrition based on PG-SGA score and esophageal and gastric cancers.Methods: A case-control study was conducted, including ۱۲۰ patients with upper GI cancers as cases and ۱۲۰ patients with orthopedic, ear-nose-throat (ENT), and neurologic disorders as controls group. These patients have been newly diagnosed using endoscopy, imaging, or biopsy techniques. The general and PG-SGA questionnaires were completed by the participants.Results: The mean ± SD of PG-SGA score was ۶۹.۲% and ۴۳.۳% in cases and controls, respectively. Cancer was significantly associated with the higher PG-SGA score, family history of cancer, poor economic level, and lower household employed people (P<۰.۰۵).Conclusion: These results suggest that a higher PG-SGA score may contribute to the incidence of upper GI cancers.

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Keywords: PG-SGA , Body mass index , Upper Gastrointestinal Neoplasms