Selective and low-cost potentiometric sensors to determine fexofenadine and rupatadine in pharmaceuticals using sodium tetraphenyl boron as an ion-exchanger

In this study, we designed two simple, selective and cost-effective solid-state ion-selective sensors using a polyvinylchloride matrix to detect fexofenadine hydrochloride (FFH) and rupatadine fumarate (RTF) in pharmaceuticals. These sensors utilize the sodium tetraphenyl boron (NaTPB) for ion exchange and β-cyclodextrin for ionophore properties. The FFH sensor shows a linear response within the range of 5 × 10-4 to 2.5 × 10-3 mol L-1 of FFH at pH levels ranging between 2.5 and 6, exhibiting a Nernstian slope of 56.92 mV/decade. Similarly, the RTF sensor demonstrates a linear response between 8 × 10-5 and 2.5 × 10-3 mol L-1 of RTF within the pH range of 2.8 – 6.4, with a Nernstian slope of 20 mV/decade. Detection and quantification limits of FFH were found to be 2.5 × 10-4 and 4.5 × 10-4 mol L-1, and that of RTF were 2.0 × 10-5 and 6.1 × 10-5 mol L-1, respectively. The sensors exhibited excellent selectivity, as indicated by mean percentage recoveries of 100.7 and 99.87 for FFH and RTF, respectively, with a low relative standard deviation (RSD) of less than 2.5 %.

Selective and low-cost potentiometric sensors to determine fexofenadine and rupatadine in pharmaceuticals using sodium tetraphenyl boron as an ion-exchanger Keywords:

Fexofenadine , Rupatadine , Sodium tetraphenyl boron , Nernstian slope , Sensors