Which of the following tests aspartate aminotransferase, alanine transaminase and alkaline phosphatase, can predict poor outcomes in Coronavirus ۲۰۱۹ patients? a retrospective cohort study

Background:Coronavirus ۲۰۱۹ (COVID-۱۹) disease caused a recent pandemic that killed thousands of people by causing mild and severe systemic organ involvement. Researchers are still trying to find the proper diagnosis tool for the disease. In addition, we investigated the effect of aspartate aminotransferase (AST), alanine transaminase (ALT), and alkaline phosphatase (ALP) enzymes on long-term outcomes.Methods:The variables in this retrospective cohort study were collected from the records of patients with Covid-۱۹ referred to Rouhani Hospital in Mazandaran, northern Iran. Patients were followed up to the cut-off points for mortality.Results:Among ۳۲۰ eligible patients, AST levels, unlike ALT and ALP, were significantly associated with mortality (p<۰.۰۰۱) and disease severity (p=۰.۰۱۶). The level of AST, unlike the level of other tests examined at the time of referral, has a significant effect on mortality at admission time (p < ۰.۰۰۱, ۹۵% CI= ۲.۴۳۳ to ۲۰.۴۶۳, MD = ۷.۰۵۶) and time of admission to the intensive care unit (ICU) (P = ۰.۰۱۲, ۹۵% CI= ۱.۲۹۱ to ۷.۹۰۷, MD = ۳.۱۹۵). None of the tests (AST, ALT and ALP) could predict long-term mortality in patients.Conclusions:AST levels, unlike ALP and ALT levels, have shown an excellent ability to predict mortality and severity at admission, but neither of AST, ALT and ALP predicted long-term adverse outcomes.

Keywords:

COVID-۱۹ , Aspartate Aminotransferase , Alkaline phosphatase , alanine transaminase