Investigating the Effect of Pentoxifylline and Zinc Oxide Combination on Experimental Full-Thickness Wound Healing in Rats
Publish place: Iranian Journal of Veterinary Surgery، Vol: 18، Issue: 1
Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJVS-18-1_002
تاریخ نمایه سازی: 8 خرداد 1403
Abstract:
This paper aims to investigate the effect of topical application of pentoxifylline and zinc oxide combination on experimental full-thickness wound healing in rats. Forty-eight adult male Wistar rats weighing ۲۵۰ to ۳۰۰ g were randomly divided into four groups of ۱۲: Control (C), Zinc oxide (Z), Pentoxifylline (P), and Zinc-Pentoxifylline (ZP). For topical use of pentoxifylline, the ointment was formulated as ۵%. All rat were anesthetized by intraperitoneal administration of a combination of xylazine ۲% and ketamine ۱۰% and after transfer to the operating table, under aseptic conditions, using a sterile ruler and surgical razor, a ۲×۲ cm۲ skin defect in the back was created. In order to manage the wound, each group received appropriate treatment. In the ZP group, the combination of pentoxifylline and zinc oxide was treated in a ratio of ۱:۱. On days ۷, ۱۴, and ۲۱ after facilitation, a subgroup of each main group was sampled, then the samples were examined macroscopically and microscopically. At the end of this period, the highest percentage of the healing, wound closure, and keratinocyte migration and the lowest inflammation belonged to the PZ group. The rate of inflammation and the number of inflammatory cells at the end of the period were lower in the ZP group than Z group and there was a statistically significant difference (p ≤ ۰.۰۵). Overall, this study showed that wound healing is performed with better speed and quality following topical application of a combination of zinc oxide and pentoxifylline. However, more studies are needed to confirm this conclusion.
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Authors
Mahzad Moradi
Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
Soroush Sabiza
Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
Annahita Rezaie
Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
Masoumeh Ezzati-Givi
Department of Basic Siences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
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