Evaluation of Etomidate as an Intravenous Anesthetic Drug in Dogs: Using Midazolam and Methocarbamol in Premedication

Objective- The aim of this study was to evaluate etomidate as an injectable anesthetic in dogs and to use midazolam and methocarbamol as premedication.Design- Experimental Study.Animals- Fourteen native young female dogsProcedure- Dogs were randomly allocated to two groups to receive midazolam (۰.۵ mg/kg; MiE group) or methocarbamol (۲۰ mg/kg; MeE group) ۵ minute before etomidate (۲ mg/kg) intravenously. In addition to recording anesthesia time table, physiological and hematobiochemical parameters were also measured at different time points in two groups.Results- It was found that there was no significant difference between two groups at both induction and recovery time. Heart rate, respiratory rate, and rectal temperature changes in the MiE group were noticeably fluctuating, unlike the MeE group. There was a significant difference in the values of hematocrit, total protein, glucose, and cortisol between the two groups at some time points. Significant increase in ALT and AST activities was observed in MeE group compared to MiE group at some time points.Conclusion and Clinical Relevance- Intramuscular administration of methocarbamol or midazolam prior to etomidate not only has minimal cardiopulmonary effects and hematobiochemical changes in dogs but provide similar anesthesia and recovery time.

Keywords:

Etomidate , Midazolam , Methocarbamol , Dog