Effect of Systemic Administration of Curcumin on Ischemia-Reperfusion Injury in Ovaries: An Animal Model Study
Publish place: Iranian Journal of Veterinary Surgery، Vol: 14، Issue: 1
Publish Year: 1398
Type: Journal paper
Language: English
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Document National Code:
JR_IJVS-14-1_001
Index date: 28 May 2024
Effect of Systemic Administration of Curcumin on Ischemia-Reperfusion Injury in Ovaries: An Animal Model Study abstract
Objective-Ovarian torsion must be diagnosed and treated as much early as possible. The aim of the present study was to investigate effects of interaperitoneal administration of curcumin on ischemia-reperfusion injury in ovaries.Design- Experimental StudyAnimals- Twent-four healthy female Wistar ratsProcedures- Twent-four healthy female Wistar rats weighing approximately 260g were randomized into four experimental groups (n = 6): Group Sham: The rats underwent only laparotomy. Group I: A 3- hour ischemia only. Group I/R: A 3-hour ischemia and a 3-hour reperfusion. Group I/R/C: A 3-hour ischemia, a 3-hour reperfusion and 1 mg/kg interaperitoneal administration of curcumin 2.5 hours after induction of ischemia. Results-Curcumin treated animals showed significantly ameliorated development of ischemia and reperfusion tissue injury compared to those of other groups (P<0.05). The significant higher values of SOD, GPO and GST were observed in I/R/C animals compared to those of other groups (P<0.05). The damage indicators (MDA) was significantly lower in I/R/C animal compared to those of other groups (P<0.05).Conclusion and Clinical Relevance- Interaperitoneal administration of curcumin could be helpful in minimizing ischemia-reperfusion injury in ovarian tissue exposed to ischemia.
Effect of Systemic Administration of Curcumin on Ischemia-Reperfusion Injury in Ovaries: An Animal Model Study Keywords:
Effect of Systemic Administration of Curcumin on Ischemia-Reperfusion Injury in Ovaries: An Animal Model Study authors
Ali Javadi-Afshar
Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran.
Alireza Najafpour
Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran.
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