Effect of Systemic Administration of Curcumin on Ischemia-Reperfusion Injury in Ovaries: An Animal Model Study

Objective-Ovarian torsion must be diagnosed and treated as much early as possible. The aim of the present study was to investigate effects of interaperitoneal administration of curcumin on ischemia-reperfusion injury in ovaries.Design- Experimental StudyAnimals- Twent-four healthy female Wistar ratsProcedures- Twent-four healthy female Wistar rats weighing approximately ۲۶۰g were randomized into four experimental groups (n = ۶): Group Sham: The rats underwent only laparotomy. Group I: A ۳- hour ischemia only. Group I/R: A ۳-hour ischemia and a ۳-hour reperfusion. Group I/R/C: A ۳-hour ischemia, a ۳-hour reperfusion and ۱ mg/kg interaperitoneal administration of curcumin ۲.۵ hours after induction of ischemia. Results-Curcumin treated animals showed significantly ameliorated development of ischemia and reperfusion tissue injury compared to those of other groups (P<۰.۰۵). The significant higher values of SOD, GPO and GST were observed in I/R/C animals compared to those of other groups (P<۰.۰۵). The damage indicators (MDA) was significantly lower in I/R/C animal compared to those of other groups (P<۰.۰۵).Conclusion and Clinical Relevance- Interaperitoneal administration of curcumin could be helpful in minimizing ischemia-reperfusion injury in ovarian tissue exposed to ischemia.

Keywords:

ischemia-reperfusion , curcumin , Intraperitoneal , Ovary