Comparison of the Use of Mask or Chamber in Inducing Anesthesia with Isoflurane in Rabbits

Objective- To study the effects of Isoflurane in inducing anesthesia and comparing mask and chamber induction anesthesia in rabbits for the first trial in Iran. Design- Experimental design. Animals- ۲۰ female adult New Zealand White rabbits. Procedures- Animals were divided randomly into two groups. A ۴۰ cm۳ Chamber was used in group A with ۴-۵% concentration of isoflurane and a face mask was used in group B with ۱-۱.۵% concentration of isoflurane to induce anesthesia. The concentration of isoflurane increased in ۳۰ second intervals since reached to ۴%. Routine ovariohysterectomy was performed in both groups.  Duration of induction and recovery, apneuastic period and volume of consumed isoflurane were measured in both groups. Results- Mean duration of induction of anesthesia was significantly shorter in group B in comparison to group A (P<۰.۰۵). Apneuastic duration was lasting ۱۰ to ۹۰ sec. The volume of isoflurane delivered to animals was significantly lower in group B (۷.۱±۱.۲ ml) compared with group A (۲۴.۷±۶.۶ ml) (P<۰.۰۵). The mean duration of recovery was not significantly different in group A compared to group B (P>۰.۰۵). Conclusion and Clinical Relevance- As concluded use of isoflurane to induce anesthesia in rabbits is feasible and safe in case of available equipments. Mask induction seems more appropriate to induce anesthesia than chamber.

Keywords:

Isoflurane , Inhalation Anesthesia , Chamber , Mask , Rabbit