Evaluation of Antinociceptive Efficacy of pre Versus post-Incisional Morphine, Tramadol or Meloxicam in Rats
Publish place: Iranian Journal of Veterinary Surgery، Vol: 10، Issue: 1
Publish Year: 1394
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJVS-10-1_002
تاریخ نمایه سازی: 8 خرداد 1403
Abstract:
Objective- To evaluate antinociceptive efficacy of pre- versus post-incisional morphine, tramadol and meloxicam using tail-flick test in an incisional model of pain in rats. Design- Prospective, randomized experimental study. Animals- Eighty, adult, male Wistar rats weighing ۲۵۰–۳۰۰ g. Procedures- Animals were randomly divided into eight groups to receive pre- or post-incisional (tail skin incision) saline (۱ mL/kg, IP), morphine (۴ mg/kg, IP), tramadol (۱۲.۵ mg/kg, IP), or meloxicam (۱ mg/kg, IP). Antinociceptive effect of drugs was assessed using tail-flick latency (TFL) test following exposure to radiant heat. Results- Morphine injection before or after incision prevented hyperalgesia for ۱۲۰ minutes, while pre- or post-incisional administration of tramadol prevented hyperalgesia for ۹۰ and ۱۲۰ minutes, respectively. There was no significant difference between pre- or post-incisional administration of morphine or tramadol. Meloxicam, given either before or after skin incision, did not prevent hyperalgesia as compared with saline control group. Conclusion and Clinical Relevance- The timing of treatment had no significant effects on post-operative nociception. Both morphine and tramadol were effective in reducing post-operative hyperalgesia and can be used for the control of early postoperative nociception in rats.
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Authors
Nasser Vesal
Department of Veterinary Clinical Studies, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
Mehrzad Foroud
Resident of Surgery at Department of Surgery, School of Veterinary Medicine, Shiraz University, Shiraz, Iran