Effects of Pomegranate Seed Oil on Oxidative Stress Parameters and Lipid Profiles in Ovariectomized Rats

Publish Year: 1392
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_IJVS-8-2_003

تاریخ نمایه سازی: 8 خرداد 1403

Abstract:

Objective- This study was designed to determine the effect of pomegranate seed oil (PSO) treatment on oxidative stress and lipid profiles in ovariectomized (OVX) rats. Design- Experimental study Animals- ۲۴ female Wistar rats Procedures-The rats were randomly divided into four groups: sham-operated (SHAM), SHAM with PSO treatment (SHAM + PSO), ovariectomized (OVX), and ovariectomized with PSO treatment (OVX + PSO). OVX and SHAM rats were treated with PSO (۲۰۰ mg/kg/d) or normal saline solution (in a volume similar to PSO), orally using a stomach tube for ۸ weeks. Results- Although a significant decrease (p < ۰.۰۱) in serum total antioxidant status (TAS) concentration in the OVX group was observed when compared to the SHAM group, no significant difference was observed for TAS between OVX + PSO and SHAM groups. Rats of the OVX group presented a significant increase in LDL cholesterol concentration (p < ۰.۰۵), when compared to SHAM + PSO group. However, no significant difference was seen for LDL cholesterol between OVX + PSO and SHAM + PSO groups. No significant differences were seen for superoxide dismutase, glutathione peroxidase, malondialdehyde, triglyceride, total cholesterol and HDL cholesterol between groups. Conclusions and Clinical Relevance- The results of the present study showed that PSO might have some beneficial effects on the antioxidant status and LDL concentration after ovariectomy in rats.

Authors

Saeedeh Tahmasbi

Department of Clinical Sciences, School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.

Mohammad Heidarpour

Department of Clinical Sciences, School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.

Amir Moghaddam jafari

Department of Basic Sciences, School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.

Hossein Kazemi Mehrjerdi

Department of Clinical Sciences, School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.