Evaluation of Intravenous Lidocaine Overdose in Chickens (Gallus domesticus)
Publish place: Iranian Journal of Veterinary Surgery، Vol: 8، Issue: 1
Publish Year: 1392
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJVS-8-1_001
تاریخ نمایه سازی: 8 خرداد 1403
Abstract:
Objective- To evaluate the total toxic dose of lidocaine and serum lidocaine concentrations resulting in clinical signs of toxicity in chickens. Design- Experimental study Animals- Eight healthy, female, ۵۵-week-old chickens (Lohman breed) weighing ۱.۴۵ ± ۰.۱۷ kg (mean ± SD) Procedure- A loading dose of ۲% lidocaine (۴ mg/kg) was administered IV, followed by a constant-rate infusion at a dose of ۸ mg/kg/min using a syringe pump. Times to onset of convulsion and/or respiratory arrest were recorded and the total toxic dose of lidocaine was determined. Blood sample was withdrawn for lidocaine analysis at the onset of the major signs of intoxication (convulsion or respiratory arrest). Results- The total toxic dose of lidocaine required to produce systemic toxicity and corresponding serum lidocaine concentration were ۲۸.۹۶ ± ۶.۲۱ mg/kg and ۳۸.۵ ± ۱۰.۴ μg/mL, respectively. Conclusions and clinical relevance- Based on the results of this study, greater doses of lidocaine are needed to produce toxic manifestations in chickens as compared with mammals.
Authors
Hadi Imani
Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
Nasser Vesal
Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
Soliman Mohammadi-Samani
Pharmaceutical Science Research Center, School of Pharmacy, Shiraz University of Medical Science, Shiraz, Iran