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Investigating the effect of astaxanthin on the survival rate of MCF-7 breast cancer cells by MTT method (cytotoxicity test)

Publish Year: 1403
Type: Journal paper
Language: English
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JR_IJHES-2-1_002

Index date: 1 June 2024

Investigating the effect of astaxanthin on the survival rate of MCF-7 breast cancer cells by MTT method (cytotoxicity test) abstract

Cancer is known as a very dangerous and incurable disease, with symptoms such as pain and disability. In recent years, changes in the way people live have increased the prevalence of breast cancer in different societies. This terrible disease has increased research in this field. Astaxanthin is one of the most famous natural carotenoids, which, due to its strong antioxidant activity, can prevent cardiovascular diseases, strengthen the body's immune system, and prevent cell ageing. In this study, the effect of astaxanthin on MCF-7 cancer cells was investigated. After culturing the cells in 96-well plates, they were treated with different concentrations of astaxanthin and then evaluated using the MTT method. The results showed that astaxanthin can inhibit cell growth and induce apoptosis, and this effect is enhanced by increasing the concentration of astaxanthin, so that at a concentration of 100 μM, the rate of apoptosis increased to 35%. Therefore, it can be concluded that astaxanthin may be used as a control treatment for cancer.Cancer is known as a very dangerous and incurable disease, with symptoms such as pain and disability. In recent years, changes in the way people live have increased the prevalence of breast cancer in different societies. This terrible disease has increased research in this field. Astaxanthin is one of the most famous natural carotenoids, which, due to its strong antioxidant activity, can prevent cardiovascular diseases, strengthen the body's immune system, and prevent cell ageing. In this study, the effect of astaxanthin on MCF-7 cancer cells was investigated. After culturing the cells in 96-well plates, they were treated with different concentrations of astaxanthin and then evaluated using the MTT method. The results showed that astaxanthin can inhibit cell growth and induce apoptosis, and this effect is enhanced by increasing the concentration of astaxanthin, so that at a concentration of 100 μM, the rate of apoptosis increased to 35%. Therefore, it can be concluded that astaxanthin may be used as a control treatment for cancer.

Investigating the effect of astaxanthin on the survival rate of MCF-7 breast cancer cells by MTT method (cytotoxicity test) Keywords:

Investigating the effect of astaxanthin on the survival rate of MCF-7 breast cancer cells by MTT method (cytotoxicity test) authors

Fatemeh Teimourpour

Department of Biology, Islamic Azad University, Science and Research Unit, Tehran, Iran

Ghazal Rahmani

Department of Biology, Nedaya Rehaneh Educational Institute, Tehran, Iran

Bahar Fathalahi

Department of Biology, Iran Nuclear Industry Institute, Tehran, Iran

Hadis Shafiei

Department of Biology, Nedaya Rehaneh Educational Institute, Tehran, Iran

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Cancer is known as a very dangerous and incurable disease, ...
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