Correlation with Clinical Parameters and Genetic Markers of Thrombophilia Panel in Ischemic Strokes

Background and Aim: A stroke is the rapid loss of brain function due to a disturbance in blood supply. Age is a major risk factor for stroke. Genetic influence may be more important in younger stroke patients. Patients with positive results should receive appropriate counseling. This study is the first to comprehensively study thrombophilia genes in Iranian populations with ischemic stroke. The purpose of this study was to determine the occurrence of genetic mutations linked to thrombophilia CVD A in individuals with ischemic stroke and examine their correlation with clinical parameters and the Genetic Markers of Thrombophilia Panel. Methods: A study was conducted on 62 patients at the Department of Stroke in Shahid Beheshti Complex Hospitals, Qom University of Medical Sciences from October 2017 to October 2018. The study was approved by the Ethics Committee of Qom University of Medical Sciences. The patients were between the ages of 32 and 97 and had Ischemic stroke. In order to detect genotype mutation, the reagents used were provided by CVD Strip assay kit. (Figure 1) Results: Sixty-two patients with ischemic stroke, mean age 67.9 ±3 .76. Smoking 11.1%, hypertension 79.4%, previous diabetes and hyperlipidemia 44.4%. Women had less prevalence of risk factors. Most common mutation Polymorphism of ACE 82.5%. Second and third mutations Polymorphism of FGB 76.2% and Polymorphism of LTA 71.4%. Prevalence of polymorphism: ACE I/D 82.5%, FGB -455G>A 76.2%, LTA 804C>A 71.4%, eNOS 894G>T 52.4%, eNOS-786T>C 12.7%, Apo B R3500Q 33.3%, HPA1 a/b 31.7%, Apo E (E2E2:54%, E2E3:3. 2%, E2E4:9.5%, E3E3:14.3%, E3E4:15.9%, E4E4:1. 6%). Relationship between genes and age, sex, cigarette, hyperlipidemia, diabetes, and hypertension measured. No significant relationship found. Data analysis: All analyses were performed using the Statistical Package for Social Sciences (SPSS Version 25.0) and the statistical significance level was defined as P< 0.05. Conclusion: Thrombophilia Risk groups were separated into high- and low-risk groups. there was no significant association between demographic characteristics including age, sex, smoking, preexisting comorbidity and thrombophilia (P>0.05)

Correlation with Clinical Parameters and Genetic Markers of Thrombophilia Panel in Ischemic Strokes Keywords:

Ischemic stroke , Genetics risk factors , thrombophilia anticoagulation therapy