Biliary co-infection by multidrug-resistant Candida glabrata and Candida albicans in a case of pancreatic cancer with cholangitis: A case report and review of literature

Acute cholangitis is commonly considered a primary obstructive phenomenon due to bacteriobilia, biliary candidiasis is an area of ongoing investigation especially in immunocompromised patients with cholangitis. Moreover, the growing concerns of drug-resistant candidiasis and the emergence of multidrug-resistant (MDR) Candida species pose a serious threat to patient outcomes, especially among immunocompromised individuals. Thus, treatment of biliary candidiasis is problematic, and in many patients, eradication cannot be achieved. Candida albicans is the most frequent species isolated from biliary candidiasis followed by Candida glabrata, however, co-infection by the organisms has not been described previously. In the present study, we report a case of pancreatic cancer with cholangitis that was co-infected by MDR C. glabrata and C. albicans.

Keywords:

biliary tract , Candida albicans , Candida glabrata , candidiasis , cholangitis , drug resistance