A case series of uncommon colonic sub-epithelial lesions with subsequent endoscopic resection and follow up

Background and Aim: Sub-epithelial colonic lesions are uncommon and can be presented as a diagnostic challenge. Endoscopic resection is a minimally invasive technique that can be used to remove these lesions. This case series aims to provide further insight into the management and follow-up of patients with these uncommon lesions.Patients and Methods: Eight patients with sub-epithelial colonic lesions were included in this study. The patients' ages ranged from ۳۸ to ۷۷ years, and the majority were male (۵/۸, ۶۲.۵%). The patients presented with a variety of symptoms, including abdominal pain, GI bleeding, and constipation. All patients underwent colonoscopy, which revealed sub-epithelial lesions in the colon. The lesions were biopsied and sent for histopathological analysis. In addition, EUS was performed in all patients to assess the size, vascularity, and depth of invasion of the lesions.Findings: This article presents a series of ۸ cases of sub-epithelial colonic lesions that were successfully diagnosed and treated using a combination of endoscopic and imaging techniques. The lesions included a Schwannoma, pneumatosis cystoides intestinalis, a low-grade neuroendocrine tumor (NET), a leiomyoma, a lymphangioma, a gastrointestinal stromal tumor (GIST), a squamous cell carcinoma (SCC), and an endometrial lesion associated with endometriosis. The endoscopic findings of these lesions varied, but they all showed some degree of submucosal involvement. EUS was used to confirm the submucosal location of the lesions and to assess their size and vascularity. In all cases, the lesions were successfully resected using endoscopic techniques. The follow-up data for these patients is encouraging, with no evidence of recurrence or metastasis in any of the cases. This suggests that endoscopic resection is a safe and effective treatment for sub-epithelial colonic lesions.