Simultaneous Evaluation of Triclosan and Methylparaben in Some Personal Care Products Using Green Spectrophotometric Techniques

Pharmaceutical personal care products, which include both prescription and over-the-counter chemicals, are categorized as "emerging contaminants". Triclosan serves as a substance that kills bacteria, while methylparaben acts as a preservative that prevents the growth of microorganisms in medicinal personal care items. Three accurate, rapid, simple, inexpensive, and green spectrophotometric methods were developed for the simultaneous determination of triclosan and methylparaben in a binary mixture in some personal care products. The first technique is the “second derivative peak-to-baseline” was selected at the selected wavelengths. The second technique is the ratio spectra derivative. The third one is the “mean centering ratio derivative spectra”. The proposed techniques were successfully applied to some real samples. The suggested approaches' effectiveness is demonstrated by the recovered values that varied from ۹۶.۴۰% to ۱۰۰.۷۵% with an RSD less than ۳.۸۴%. The methods were verified in accordance with “ICH” guideline; interference, accuracy, and precision were found to be within acceptable value. Statistical comparisons of the precision and accuracy of the outputs from the suggested methods and the methods provided reveal no discernible differences when using One-way ANOVA. Lastly, the proposed techniques are measured as the "greenness" profile.

Keywords:

Derivative Spectrophotometry , ratio spectra derivative method , mean centering ratio derivative spectra , Triclosan , Methylparaben