A quantitative analysis of the impact of cellular replication, radioactive decay, andemitted energy on targeted radiotherapeutic approaches

This study aims to investigate the impact of cell proliferation on tumor treatment. Two scenarios wereexamined: ۱) nonproliferation of tumor cells, where the survival curve of irradiated cells follows an exponentialfunction of accumulated dose, and ۲) exponential proliferation of tumor cells with a growth constant throughoutirradiation. In nonproliferation, the fraction of surviving tumor cells decreases over time. In proliferation cases,initial irradiation reduces the fraction of cells. If the remaining fraction is sufficiently reduced, the tumor may betreated; otherwise, the decreasing dose rate fails to sterilize proliferation, leading to increased tumor cellpopulation.

Keywords:

Targeted Radiotherapy , Cell Proliferation , Dose‑Rate