Evaluation of the prevalence of Mycoplasma hominis in pregnant women with Premature rupture of membranes and the control group by culture and PCR methods in northwest Iran

Introduction: Premature rupture of membranes (PROM) is a serious perinatal problem that may be associated with bacterial infections. The aim of this study was to evaluate the prevalence of cervical infection with Mycoplasma hominis (M. hominis) in patients with PROM. Methods: This case-control study was conducted on ۱۰۰ pregnant women with PROM and ۵۰ healthy asymptomatic pregnant women (control) in Tabriz Women's Hospital. Cervical swab samples were collected and analyzed using culture and polymerase chain reaction (PCR) techniques to identify M. hominis. Data were analyzed using Statistical package for social science (SPSS) software and Chi-square statistical tests. Results: M. hominis was detected in ۲۰% and ۴۹% of PROM patients by culture and PCR method, and ۷% and ۱۰% of pregnant women in the control group by culture and PCR method. A statistically significant relationship was observed between age group, history of abortion, vaginal infection before pregnancy and spontaneous rupture of membranes in pregnant women with the risk of contracting M. hominis followed by PROM in pregnant women Conclusion: The results of this study showed that cervical infection with M. hominis has a significant relationship with PROM. Therefore, screening and treatment of mycoplasma infections in pregnant women can be effective in preventing PROM.

Keywords:

Mycoplasma hominis , pregnancy , premature rupture of membranes