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Encapsulation of protein in poly(lactic-co-glycolic acid) nanofibers by emulsion electrospinning

Publish place: National Conference on Nanotechnology and Green Chemistry
Publish Year: 1391
Type: Conference paper
Language: English
View: 1,301

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Link to this Paper:
https://civilica.com/doc/203377

Document National Code:

IAUET01_107

Index date: 30 June 2013

Encapsulation of protein in poly(lactic-co-glycolic acid) nanofibers by emulsion electrospinning abstract

In this study, nanofibrous scaffolds of poly(lactic-co-glycolic acid) (PLGA) through electrospinning technique were fabricated. Also, PLGA nanofibers with a core-sheath structure encapsulating bovine serum albumin (BSA) as a model protein for hydrophilic bioactive agents were prepared through emulsion electrospinning technique. Morphology of the nanofibers and the core-sheath structure of the emulsion electrospun nanofibers were observed by field-emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM), respectively. The results of protein release assay demonstrated a sustained release profile of BSA. The nanofibrous scaffold with the capability of encapsulation and controlled release of the protein can be served in tissue engineering applications.

Encapsulation of protein in poly(lactic-co-glycolic acid) nanofibers by emulsion electrospinning Keywords:

Emulsion electrospinning , Nanofibrous scaffold , Controlled release , PLGA

Encapsulation of protein in poly(lactic-co-glycolic acid) nanofibers by emulsion electrospinning authors

Mohammad Norouzi

Young Researchers and Elites Club, Science and Research Branch, Islamic Azad University, Tehran, Iran -Department of Nanotechnology and Tissue Engineering, Stem Cell Technology Research Center, Tehran, Iran

Iman Shabani

Department of Polymer Engineering and Color Technology, Amirkabir University of Technology, Tehran, Iran -Department of Nanotechnology and Tissue Engineering, Stem Cell Technology Research Center, Tehran, Iran

Fatemeh Atyabi

Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Masoud Soleimani

Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

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