Fasting Blood Glucose and Insulin Level in Opium Addict versus Non-Addict Individuals

Background: Many of lay person believe that opium lowers blood glucose. However some studies show the opposite results. In this study, we tried to evaluate the effect of opium on blood glucose and insulin resistance. Methods: This comparative study including ۵۳ addicts in case groups who used opium just in the form of smoking and ۵۵ non-addicts in a control group, took part in the study, after proving not to be opium users. After taking blood samples, their fasting blood glucose (FBG), fasting blood insulin and lipid profiles were evaluated. Furthermore, insulin resistance index was analyzed via the homeostatic model assessment of insulin resistance (HOMA-IR) formula with the cut-off points of ۷.۲ and ۷.۱. Findings: Age and gender were not significantly different between the groups. There was no significant difference regarding the prevalence of insulin resistance between the two groups, according to the cut-off points of ۷.۱ and ۷.۲ (P = ۰.۱۹۶ and P = ۰.۲۴۸, respectively). Mean insulin resistance index was not significantly different between the two groups (P = ۰.۳۲۵). In the case group, fasting blood insulin was considerably lower (P = ۰.۰۲۵) and fasting blood sugar (FBS) was significantly higher (P = ۰.۰۱۶) than the control group. Conclusion: According to the level of insulin and FBS in addicts, it does not seem that opium has a significant effect on reducing the blood glucose and insulin resistance.

Keywords:

opium addiction , Blood Sugar , insulin resistance