The Effect of Aerobic Training Combined With Martighal Consumption on Vascular Endothelial Growth Factor and Homocysteine in Sedentary Women with Metabolic Syndrome

Introduction: Recently, the role of using medicinal plants during exercise training has been expanded with the aim of improving antioxidant and cardiovascular function in healthy and sick obese populations.In this study, the aim is to investigate the effect of aerobic training combined with Martighal extract on the serum levels of vascular endothelial growth factor (VEGF) and homocysteine in female with metabolic syndrome. Methods: In this clinical trial, ۴۸ obese females (۳۰ ≤ BMI ≤ ۳۶, ۸۴.۴۵  ± ۵.۴۱ kg) diagnosed with metabolic syndrome aged ۳۰-۴۵ years of old were randomly allocated into four distinct groups: control (no intervention); Martighal extract (۲۸۰ mg /daily); aerobic training (alternate days) and combined group (aerobic training + Martighal). Baseline concentrations of fasting VEGF and homocysteine, along with anthropometric measurements, were recorded prior to and ۴۸ hours subsequent to the final training session for each group. To analyze the data, Analysis of Covariance (ANCOVA) was employed for inter-group comparisons, while the paired-sample t-test was utilized to assess intra-change in each group (P ≤ ۰.۰۵). Results: Compared to control group, serum VEGF significantly increased in the aerobic, Martighal and combined groups (P=۰.۰۰۱).There was no significant difference in homocysteine levels in response to the interventions (P=۰.۹۱۹). Conclusion: Despite the mentioned evidence, the effectiveness of Martighal consumption during aerobic exercise cannot be emphasized only by improving VEGF, and it is suggested to measure other markers of vascular endothelial function in order to obtain the mechanisms responsible for Martighal supplementation during exercise in this patients.

Keywords:

Vascular endothelial function , Aerobic training , Martighal extract , metabolic syndrome