Investigation of the Relationship Between Polymorphism in miR-۳۴b/c and Risk of Alzheimer’s Disease
Publish place: Human Genetics and Genomics، Vol: 4، Issue: 2
Publish Year: 1399
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_JHGG-4-2_005
تاریخ نمایه سازی: 1 شهریور 1403
Abstract:
The significant role of microRNAs (miRNAs) in gene expression regulation has been demonstrated. Changes in the expression of miRNAs have been reported in a variety of neurological diseases. However, the role of miR-۳۴b/c in the risk of Alzheimer’s disease has been less studied. Therefore, the current study aims to investigate the relationship between miR-۳۴b/c polymorphism and the risk of Alzheimer’s disease. This study was performed with ۴۰ Alzheimer’s patients and ۴۰ controls. Using the polymerase chain reaction technique to investigate polymorphisms in the miR-۳۴b/c gene. The results of this study indicated an association between miR-۳۴ b/c polymorphisms and the risk of Alzheimer’s disease.