Comparing the Effect of Nifedipine and Indomethacin on Pregnant Women with Idiopathic Preterm Labor

Aims: In preterm delivery, uterine contractions begin prematurely and lead to the opening of the cervix. Nifedipine and Indomethacin drugs can help reduce contractions and delay childbirth.  However, there are contradictions regarding their effect on preterm birth and inflammatory factors. This study aimed to compare the effect of nifedipine and indomethacin on uterine contractions, CRP, and white blood cells in pregnant women with idiopathic preterm labor. Material and Methods: This single-blind clinical trial was conducted on ۶۸ eligible pregnant women hospitalized with premature labor pains in Imam Sajjad Yasuj Hospital in ۲۰۲۲ and randomly assigned to two groups. With tocography, the fixation contractions must have at least four contractions higher than ۱۵mmHg. Before and ۴۸h after interventions, the number and time of contractions, cervical dilatation, WBC, DIFF, and CRP tests were measured. Data were analyzed using SPSS ۲۵ software. Findings: Both interventions improved the number and time of contractions, CRP, and neutrophil. However, there were no significant differences in these variables between Nifedipine and Indomethacin groups. The study showed a statistically significant difference between groups in the number of eosinophils and monocytes after the intervention (p<۰.۰۵). Conclusion: Nifedipine and Indomethacin improve the number and duration of contractions, CRP, monocytes, and neutrophils. Nifedipine causes more decrease in eosinophil levels than indomethacin.

Keywords:

Nifedipine , Indomethacin , Number of Uterine Contractions , Idiopathic Preterm Labor