The Effect of Physical Exercise on Expression of Endogenous Bioactive Peptides with Pro-and Anti-Atherogenic Properties
Publish place: Journal of Exercise and Health Science، Vol: 2، Issue: 4
Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_JEHS-2-4_002
تاریخ نمایه سازی: 10 شهریور 1403
Abstract:
The prevalence of atherosclerotic cardiovascular disease (ASCVD) and its complications have increased substantially in recent decades. ASCVD is associated with cardiovascular diseases and is an indirect cause of a high death rate in the general population. Salusin-α and salusin-β are two endogenous bioactive peptides that could be candidate biomarkers for ASCVD. Salusin-α protects against the development of ASCVD, and a decrease in its levels is associated with ASCVD. While salusin-β plays a role in the development and/or maintenance of ASCVD and the exaggerated expression in atherosclerotic lesions. Changes in people's lifestyles, especially sedentary behavior, and a lack of exercise, are recognized as critical risk factors for cardiovascular disease. Hence, physical exercise (PE) recently had been identified as effective strategies for lowering cardiovascular disease risk. In this review, we summarize the current knowledge on the effects of PE on ASCVD through modulation of the expression of endogenous bioactive peptides with pro-and-anti-atherogenic properties.
Authors
Alireza Paahoo
Research Working Group, General Directorate of Education, Scientific Association of Physical Education Teachers, Kermanshah, Iran.
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