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A Basic Strategic Approach for Method Development by Inductively Coupled Plasma Mass Spectrometry (ICP-MS): A Review

Publish Year: 1403
Type: Journal paper
Language: English
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JR_JEIR-5-1_004

Index date: 5 September 2024

A Basic Strategic Approach for Method Development by Inductively Coupled Plasma Mass Spectrometry (ICP-MS): A Review abstract

Method development for ICP-MS entails optimizing parameters to ensure precise and accurate elemental measurements. Sample preparation involves selecting techniques like digestion and dilution. Instrument setup optimizes plasma power and calibration with certified reference materials. Mass selection considers sensitivity and interference. Background correction methods account for spectral interferences. Internal standards correct for variations. Quality control ensures accuracy through replicate analyses and spike recoveries. Data analysis involves quantification and validation based on regulatory guidelines. Method optimization refines parameters for improved sensitivity and robustness. Comprehensive documentation and SOPs maintain consistency. Validation assesses accuracy, precision, and linearity according to standards like USP and ICH. Overall, this systematic approach guarantees reliable elemental analysis using ICP-MS.

A Basic Strategic Approach for Method Development by Inductively Coupled Plasma Mass Spectrometry (ICP-MS): A Review Keywords:

A Basic Strategic Approach for Method Development by Inductively Coupled Plasma Mass Spectrometry (ICP-MS): A Review authors

Amitkumar J Vyas

Department of Pharmaceutical Quality Assurance, B. K. Mody Government Pharmacy College, Rajkot, Gujarat, India

Nensi Santoki

Department of Pharmaceutical Quality Assurance, B. K. Mody Government Pharmacy College, Rajkot, Gujarat, India

Dhruvi U. Parmar

Department of Pharmaceutical Quality Assurance, B. K. Mody Government Pharmacy College, Rajkot, Gujarat, India

Ajay I Patel

Department of Pharmaceutical Quality Assurance, B. K. Mody Government Pharmacy College, Rajkot, Gujarat, India

Ashvin V. Dudhrejiya

Department of Pharmaceutical Quality Assurance, B. K. Mody Government Pharmacy College, Rajkot, Gujarat, India

Sunny R. Shah

Department of Pharmaceutics, Government Pharmacy College, Gandhinagar, Gujarat, India

Devang B. Sheth

Department of Pharmacology, L. M. College of Pharmacy, Ahmedabad, Gujarat, India

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