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Anticancer Activity of Lactobacillus sp. Isolated from Goat Feces against Vero and HeLa Cell Lines

Publish Year: 1403
Type: Conference paper
Language: English
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ZISTCONF03_046

Index date: 8 September 2024

Anticancer Activity of Lactobacillus sp. Isolated from Goat Feces against Vero and HeLa Cell Lines abstract

Interoduction: Cancer remains a major global health concern, and the continuous emergence of drug resistancenecessitates exploration of novel therapeutic agents. Probiotics, live microorganisms with health benefits, havegained interest for their potential anticancer properties. This study investigated the anticancer activity of a cell-free culture derived from Lactobacillus plantarum isolated from Merkhoz goat feces. Methodology: L. plantarumwas isolated and confirmed using 16S rRNA gene sequencing. Cell-free culture supernatant was obtained andevaluated for its cytotoxic effects on HeLa (human cervical cancer) and Vero (monkey kidney) cell lines using theMTT assay. Discussion and conclusion: The cell-free culture exhibited concentration-dependent cytotoxicity onboth cell lines. Significant (p<0.05) lethality was observed at concentrations of 10 and 5 μl/ml on HeLa cells, andat all tested concentrations (2.5, 5, and 10 μl/ml) on Vero cells. This study demonstrates the promising in vitroanticancer activity of L. plantarum cell-free culture against HeLa and Vero cell lines. The results suggest potentialroles for organic acids and exopolysaccharides in this effect. Future research focusing on in vivo models andidentification of bioactive components is necessary to explore the potential of this probiotic strain as atherapeutic strategy for cancer.

Anticancer Activity of Lactobacillus sp. Isolated from Goat Feces against Vero and HeLa Cell Lines Keywords:

Anticancer Activity of Lactobacillus sp. Isolated from Goat Feces against Vero and HeLa Cell Lines authors

Aram Sharifi

Department of Animal Science, Faculty of Agriculture, University of Kurdistan, Sanandaj, Iran