Synthesis of a New Series of 1,3,4-Oxadizole-Based Azo Derivatives and In Vitro Evaluation of their Antibacterial Activities

A new series of 1,3,4-oxadizole-containing azo derivatives were synthesized in this research. The structural properties of the newly-synthesized compounds were assessed by IR and 1H- and 13C-NMR spectroscopic techniques. The antibacterial properties of the synthesized azo compounds were evaluated against Gram-negative and Gram-positive bacteria in vitro, revealing broader antibacterial spectrum on both bacteria groups for derivatives containing indole ring. In particular, most compounds had antibacterial effects on Staphylococcus aureus (ATCC 25923), while Pseudomonas aeruginosa (ATCC 27853) exhibited resistance against all azo compounds.

Synthesis of a New Series of 1,3,4-Oxadizole-Based Azo Derivatives and In Vitro Evaluation of their Antibacterial Activities Keywords:

oxadiazole , Indole , Salicylic Acid , Pyrazole , antibacterial