The Impact of Glutamine Mouthwash on Preventing Mucositis Following Administration of High Doses of Methotrexate in Children with Acute Lymphoblastic Leukemia: A Randomized Clinical Trial
Publish place: Middle East Journal of Cancer، Vol: 15، Issue: 4
Publish Year: 1403
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_MISJ-15-4_005
تاریخ نمایه سازی: 27 مهر 1403
Abstract:
Background: Acute lymphoblastic leukemia (ALL) represents the predominant childhood cancer. High-dose methotrexate is integral to leukemia treatment protocols. This study aimed to explore the efficacy of glutamine in preventing mucositis among leukemia patients undergoing high-dose methotrexate therapy.Method: This randomized clinical trial encompassed ۴۵ patients (۲۲ in the glutamine group and ۲۳ in the placebo group). The intervention group was administered a glutamine mouthwash, while the control group received an identical placebo. Data analysis was performed using SPSS version ۲۳, with a significance threshold set at P < ۰.۰۵.Results: No significant difference emerged between the groups concerning the incidence of nausea and vomiting; however, both groups observed a notable reduction in nausea frequency from the first to the fourth days (P = ۰.۰۰۰۱ and P = ۰.۰۴۰, respectively). Grades III and IV mucositis were absent in both groups on the third and seventh days post-treatment. Furthermore, no significant difference was detected in mucositis improvement between the groups (P = ۰.۸۴۸).Conclusion: Glutamine mouthwash significantly reduced the incidence of nausea and vomiting, which are common chemotherapy complications. Moreover, up to ۹۵% of patients were free from mucositis by the seventh-day post-chemotherapy.
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Authors
Mohammad Naderisorki
Thalassemia Research Center (TRC), Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran
Hossein Karami
Department of Clinical Pharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
Ebrahim Salehifar
Department of Clinical Pharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
Helieh Jafari
Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran
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