Assessing ABO Blood Group Relation with Collateral Coronary Circulation Development Quality

Background & Objective:  Clinical outcomes of IHD depend on various factors, and coronary collateral circulation (CCC) development has recently been studied more. This study assessed blood groups' effect on CCC formation and patency.  Materials & Methods:  In this retrospective study, all patients From January ۲۰۲۱ to August ۲۰۲۲, who had been hospitalized in the cardiac care unit of Shahid Madani Cardiology Hospital in Tabriz, Iran, were studied. ABO blood group typing was done with the Sinagene blood group determining kit. Collateral coronary circulation was assessed based on the Rentrop-Cohen grading scale for coronary arteries with ۱۰۰% occlusion (CTO). Results: ۱۶۸ of ۲۰۰ enrolled patients had well, and ۳۲ had poor CCCs based on Rentrop scales. A+ blood groups were significantly more prevalent in patients with a good Rentrop scale, and A-, B- and AB- blood groups were significantly more prevalent in the poor CCC group. ۲۱ patients in poor Rentrop and ۶۸ in the good Rentrop group had hypertension (P = ۰.۰۰۹). Seventeen patients in the poor and ۵۵ in the good Rentrop groups had DM (P = ۰.۰۲۸). The history of chronic kidney disease in poor Rentrop patients with ۱۲ cases was significantly more than the good Rentrop group with ۴ cases (P=۰.۰۰۰). The two groups had a significant difference in HLP prevalence (۰.۰۲۶).  Conclusion:  This study showed DM, hyperlipidemia, hypertension, and A-, AB- and B- blood groups were strong predictors of poor and A+ for good CCC development.

Keywords:

Coronary collateral circulation , RH blood type , O blood group , Non-O blood groups