Curcumin Ameliorates Depression, and Anxiety in Patients with Premenstrual Syndrome and Dysmenorrhea: A Triple-Blinded Placebo-Controlled Trial

Background & Objective:  Premenstrual syndrome (PMS) and primary dysmenorrhea (PD) are gynecological conditions that are associated with psychological and mood disorders. This study assessed the effects of curcumin, a natural polyphenol, on depression, anxiety, stress and quality of life (QL) in woman with PMS and PD.  Materials & Methods: The study was undertaken in 128 women who were randomised to treatment with either curcumin (n=64) or placebo (n=64) groups. Each subject received one capsules (500 mg of curcuminoids plus 5 mg piperine, or a placebo, plus 5 mg piperine) daily, for 3 successive menstrual cycles. Psychological status and QL were assessed using Depression, Anxiety, Stress Scales-21 (DASS-21) and the Short Form-12 (SF-12) questionnaires respectively.  Results: Overall scores as well as the mental health domain of the SF-12 improved significantly after curcumin supplementation (P<0.05). In addition, curcumin decreased significantly (P<0.05) all of the DASS-21 domains (depression, anxiety and stress). Significant differences were also found between the two groups for the DASS-21 domains, SF-12 mental health (total) and overall scores (P<0.05). Conclusion: Curcuminoids may be useful as a natural, widely accessible therapeutic option for the management of the psychological impact of PMS and PD, and improve the QL of women with these conditions.

Curcumin Ameliorates Depression, and Anxiety in Patients with Premenstrual Syndrome and Dysmenorrhea: A Triple-Blinded Placebo-Controlled Trial Keywords:

Curcumin , Menstruation , Personality , Gynecology , Anxiety