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Blending of Polyethylene Glycols with Different Molecular Weights:Physical Properties and Ibuprofen Delivery

Publish place: 16th International Seminar on Polymer Science and Technology (ISPST 2024)
Publish Year: 1403
Type: Conference paper
Language: English
View: 68

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Link to this Paper:
https://civilica.com/doc/2106163

Document National Code:

ISPST16_053

Index date: 30 October 2024

Blending of Polyethylene Glycols with Different Molecular Weights:Physical Properties and Ibuprofen Delivery abstract

Polyethylene glycols (PEG) in different molecular weights are used as water-soluble carriers todeliver a long list of therapeutic agents to rectal mucosa. However, the necessary physical propertiesor drug delivery kinetics are rarely achieved using a single PEG with a definite average molecularweight and polydispersity index implying a certain need for blending. To this end, PEGs in differentmolecular weights (MW=2000-10000 g.mol-1) were used in alone or as 50:50 dual blends toformulate ibuprofen (IBU) suppositories. Physical and drug delivery characteristics of the deviceswere investigated supporting that 50:50 blends of PEG 2000:10000 and PEG 4000:10000 presentedthe optimal physical properties and IBU release kinetics. According to the results, difference inmolecular weight of PEGs affect drug release kinetics only at early times, i.e. 20 minutes

Blending of Polyethylene Glycols with Different Molecular Weights:Physical Properties and Ibuprofen Delivery Keywords:

Polymers in Medicine and Healthcare , PEG , Blend , Ibuprofen , Drug Delivery

Blending of Polyethylene Glycols with Different Molecular Weights:Physical Properties and Ibuprofen Delivery authors

Nikou Mortazavi

Islamic Azad University, Pharmaceutical Sciences Branch, Tehran, Iran.

Zahra Jafari Azar

Islamic Azad University, Pharmaceutical Sciences Branch, Tehran, Iran.

Mohammad Imani

Iran Polymer and Petrochemical Institute, Tehran, Iran.۳ Institute for Convergence Science & Technology, Sharif University of Technology, Tehran, Iran.