A Bioprosthetic Ovary Created Using 3D Printed Microporous Scaffolds Restores Ovarian Function in Sterilized Mice
Publish place: 14th Congress on Stem Cell Biology and Technology
Publish Year: 1397
Type: Conference paper
Language: English
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SCROYAN14_142
Index date: 3 November 2024
A Bioprosthetic Ovary Created Using 3D Printed Microporous Scaffolds Restores Ovarian Function in Sterilized Mice abstract
Background: Emerging additive manufacturing techniques enableinvestigation of the effects of pore geometry on cell behaviorand function. Here, we 3D print microporous hydrogelscaffolds to test how varying pore geometry, accomplished bymanipulating the advancing angle between printed layers, affectsthe survival of ovarian follicles.Materials and Methods: 30° and 60° scaffolds provide cornersthat surround follicles on multiple sides while 90° scaffoldshave an open porosity that limits follicle-scaffold interaction.As the amount of scaffold interaction increases, follicle spreadingis limited and survival increases.Results: Follicle-seeded scaffolds become highly vascularizedand ovarian function is fully restored when implanted in surgicallysterilized mice. Moreover, pups are born through naturalmating and thrive through maternal lactation.Conclusion: These findings present an in vivo functional ovarianimplant designed with 3D printing, and indicate that scaffoldpore architecture is a critical variable in additively manufacturedscaffold design for functional tissue engineering.Keywords: Biomaterials, preclinical research, translational research,fertility
A Bioprosthetic Ovary Created Using 3D Printed Microporous Scaffolds Restores Ovarian Function in Sterilized Mice authors
TK Woodruff
Women’s Health Research Institute, Department of Obstetrics and Gynecology, Northwestern University, Evanston, USA