Micronization of Clozapine Particles Using Rapid Expansion of Supercritical Solution with Solid Cosolvent (RESS-SC) Process
Publish place: Iranian Journal of Analytical Chemistry، Vol: 10، Issue: 2
Publish Year: 1402
Type: Journal paper
Language: English
View: 41
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Document National Code:
JR_IJAC-10-2_012
Index date: 18 November 2024
Micronization of Clozapine Particles Using Rapid Expansion of Supercritical Solution with Solid Cosolvent (RESS-SC) Process abstract
The rapid expansion of a supercritical solution (RESS) process has limited commercial applicability due to the extremely low solubility of polar drugs in supercritical CO2 (sc CO2). To overcome this major limitation, a modified process of rapid expansion of supercritical solution with solid cosolvent (RESS-SC) is proposed. Here, the RESS-SC is examined for clozapine using menthol solid as a cosolvent to reduce particle size and to increase drug solubility. In addition, the effect of extraction pressure and extraction temperature was investigated on the size and morphology of precipitated particles of clozapine. The properties of the micronized clozapine were assessed using scanning electron microscopy (SEM) and powder x-ray diffraction (XRD) techniques. In this study, the average particle size of clozapine was reduced from 29.15 (before RESS-SC) to 3.15 μm (after RESS-SC).
Micronization of Clozapine Particles Using Rapid Expansion of Supercritical Solution with Solid Cosolvent (RESS-SC) Process Keywords:
Clozapine , Rapid expansion of supercritical solution , solid cosolvent , Increase the drug solubility
Micronization of Clozapine Particles Using Rapid Expansion of Supercritical Solution with Solid Cosolvent (RESS-SC) Process authors
Majid Haji Hosseini
Nuclear Fuel cycle Research School, Nuclear Science and Technology Research Institute, Tehran, Iran